The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might lead to an increase in methadone plasma concentrations, which could cause potentially deadly respiratory melancholy. Moreover, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may additionally end in a